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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1928 1
1958 1
1963 1
1966 1
1967 1
1970 1
1971 4
1972 17
1973 19
1974 35
1975 139
1976 157
1977 137
1978 153
1979 183
1980 204
1981 273
1982 348
1983 390
1984 433
1985 499
1986 574
1987 571
1988 652
1989 695
1990 777
1991 820
1992 846
1993 990
1994 1086
1995 1180
1996 1251
1997 1390
1998 1462
1999 1584
2000 1634
2001 1722
2002 1778
2003 1840
2004 1950
2005 1987
2006 1918
2007 2031
2008 2068
2009 2057
2010 2254
2011 2481
2012 2597
2013 2619
2014 2554
2015 2569
2016 1760
2017 1433
2018 1902
2019 1922
2020 2050
2021 2050
2022 1927
2023 1679
2024 495

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60,844 results

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Page 1
Signals for antigen-independent differentiation of memory CD8(+) T cells.
Kwesi-Maliepaard EM, Jacobs H, van Leeuwen F. Kwesi-Maliepaard EM, et al. Cell Mol Life Sci. 2021 Oct;78(19-20):6395-6408. doi: 10.1007/s00018-021-03912-9. Epub 2021 Aug 16. Cell Mol Life Sci. 2021. PMID: 34398252 Free PMC article. Review.
Over the past two decades, new subsets of CD8(+) T cells have been identified that acquire memory features independently of antigen exposure. These antigen-inexperienced memory T cells (T(AIM)) are described under several names including …
Over the past two decades, new subsets of CD8(+) T cells have been identified that acquire memory features independently of …
Identifying specificity groups in the T cell receptor repertoire.
Glanville J, Huang H, Nau A, Hatton O, Wagar LE, Rubelt F, Ji X, Han A, Krams SM, Pettus C, Haas N, Arlehamn CSL, Sette A, Boyd SD, Scriba TJ, Martinez OM, Davis MM. Glanville J, et al. Nature. 2017 Jul 6;547(7661):94-98. doi: 10.1038/nature22976. Epub 2017 Jun 21. Nature. 2017. PMID: 28636589 Free PMC article.
T cell receptor (TCR) sequences are very diverse, with many more possible sequence combinations than T cells in any one individual. ...We show that GLIPH can reliably group TCRs of common specificity from different donors, and that conserved CDR3 motifs help to defi …
T cell receptor (TCR) sequences are very diverse, with many more possible sequence combinations than T cells in any one indivi …
Dietary protein shapes the profile and repertoire of intestinal CD4+ T cells.
Lockhart A, Reed A, Rezende de Castro T, Herman C, Campos Canesso MC, Mucida D. Lockhart A, et al. J Exp Med. 2023 Aug 7;220(8):e20221816. doi: 10.1084/jem.20221816. Epub 2023 May 16. J Exp Med. 2023. PMID: 37191720 Free PMC article.
The intestinal immune system must tolerate food antigens to avoid allergy, a process requiring CD4+ T cells. Combining antigenically defined diets with gnotobiotic models, we show that food and microbiota distinctly influence the profile and T cell rec …
The intestinal immune system must tolerate food antigens to avoid allergy, a process requiring CD4+ T cells. Combining anti …
Surface-linked liposomal antigen induces IgE selective unresponsiveness in a T-cell independent fashion.
Uchida T. Uchida T. Curr Drug Targets Immune Endocr Metabol Disord. 2003 Jun;3(2):119-35. doi: 10.2174/1568008033340252. Curr Drug Targets Immune Endocr Metabol Disord. 2003. PMID: 12769784 Review.
During the course of an investigation intended to clarify the mechanism of IgE-selective unresponsiveness induced by surface-coupled liposomal antigens, we discovered an alternative approach to regulate the production of IgE, one that is independent of the activity …
During the course of an investigation intended to clarify the mechanism of IgE-selective unresponsiveness induced by surface-coupled liposom …
Endogenous TAP-independent MHC-I antigen presentation: not just the ER lumen.
Del Val M, Antón LC, Ramos M, Muñoz-Abad V, Campos-Sánchez E. Del Val M, et al. Curr Opin Immunol. 2020 Jun;64:9-14. doi: 10.1016/j.coi.2019.12.003. Epub 2020 Jan 11. Curr Opin Immunol. 2020. PMID: 31935516 Review.
Altered and infected cells are eliminated by CD8(+) cytotoxic T lymphocytes. This requires production of antigenic peptides mostly in the cytosol, transport to the endoplasmic reticulum (ER) by the transporter associated with antigen processing (TAP), and cel …
Altered and infected cells are eliminated by CD8(+) cytotoxic T lymphocytes. This requires production of antigenic peptides mo …
Antigen-independent changes in naive CD4 T cells with aging.
Linton PJ, Haynes L, Klinman NR, Swain SL. Linton PJ, et al. J Exp Med. 1996 Nov 1;184(5):1891-900. doi: 10.1084/jem.184.5.1891. J Exp Med. 1996. PMID: 8920876 Free PMC article.
There is good evidence that no cross-reacting antigens for the Tg TCR recognizing pigeon cytochrome c are found in the environment of the animal, so that alterations in the Tg CD4+ cells with aging are likely to be due to antigen-independent processes. ...The …
There is good evidence that no cross-reacting antigens for the Tg TCR recognizing pigeon cytochrome c are found in the environment of …
Molecular analysis of antigen-independent adhesion forces between T and B lymphocytes.
Amblard F, Auffray C, Sekaly R, Fischer A. Amblard F, et al. Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):3628-32. doi: 10.1073/pnas.91.9.3628. Proc Natl Acad Sci U S A. 1994. PMID: 7909604 Free PMC article.
The low-affinity interactions underlying antigen recognition by T-cell receptors (TCRs) are thought to involve antigen-independent adhesion mechanisms. Using a hydrodynamic approach, we found that antigen-independent adhesion occurred bet …
The low-affinity interactions underlying antigen recognition by T-cell receptors (TCRs) are thought to involve antigen- …
Antigen presenting cells.
Hamilos DL. Hamilos DL. Immunol Res. 1989;8(2):98-117. doi: 10.1007/BF02919073. Immunol Res. 1989. PMID: 2659691 Review.
These discoveries have merged nicely with detailed immunologic studies delineating the 'minimal antigenic peptides' of complex protein antigens. All of these studies strongly confirm the belief that the antigen-specific interaction of T cells with a …
These discoveries have merged nicely with detailed immunologic studies delineating the 'minimal antigenic peptides' of complex protei …
Comparing antigen-independent mechanisms of T cell regulation.
Allan MJ, Callard R, Stark J, Yates A. Allan MJ, et al. J Theor Biol. 2004 May 7;228(1):81-95. doi: 10.1016/j.jtbi.2003.12.008. J Theor Biol. 2004. PMID: 15064084
Key features of the kinetics of T lymphocyte proliferative responses are remarkably insensitive to the nature of the antigenic stimulus. This consistency suggests the presence of an antigen-independent mechanism regulating T cell clonal expansio …
Key features of the kinetics of T lymphocyte proliferative responses are remarkably insensitive to the nature of the antigenic …
Selection, engineering, and in vivo testing of a human leukocyte antigen-independent T-cell receptor recognizing human mesothelin.
Hiscox MJ, Wasmuth A, Williams CL, Foot JN, Wiedermann GE, Fadda V, Boiani S, Cornforth TV, Wikiert KA, Bruton S, Cartwright N, Anderson VE, Barnes CS, Vieira JV, Birch-Machin I, Gerry AB, Miller K, Pumphrey NJ. Hiscox MJ, et al. PLoS One. 2024 Apr 4;19(4):e0301175. doi: 10.1371/journal.pone.0301175. eCollection 2024. PLoS One. 2024. PMID: 38574067 Free PMC article.
BACKGROUND: Canonical alpha/beta T-cell receptors (TCRs) bind to human leukocyte antigen (HLA) displaying antigenic peptides to elicit T cell-mediated cytotoxicity. ...In this proof-of-concept study, we sought to identify and engineer so-called HLA- …
BACKGROUND: Canonical alpha/beta T-cell receptors (TCRs) bind to human leukocyte antigen (HLA) displaying antigenic pep …
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